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Diclofenac is a prescription non-steroidal anti-inflammatory drug used to treat pain, inflammation and fever. Diclofenac is best for mild to moderate pain. Diclofenac works by reducing the levels of prostaglandins, bringing down pain, inflammation and fever. The symptoms Diclofenac can treat usually result from conditions like osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Diclofenac can also be prescribed for treating menstrual cramps and some of the symptoms of tendinitis. It's usually taken with some food to lessen stomach upset.